Scientific Studies

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Scientific Studies

Our ingredients and the studies to back them up

Vitamin A

http://www.westonaprice.org/ask-the-doctor/steroid-drugs
http://ajcn.nutrition.org/content/9/4/36.abstract

Vitamin C

http://journals.lww.com/nsca-jscr/abstract/1998/08000/effects_of_ascorbic_acid_on_serum_cortisol_and_the.10.aspx
http://www.ncbi.nlm.nih.gov/pubmed/19223675
http://www.ncbi.nlm.nih.gov/pubmed/17616774
http://www.ncbi.nlm.nih.gov/pubmed/6668225

Thiamine (B1), Riboflavin (B2), Pyridoxine (B6), Pantothenic Acid (B5)

http://www.ncbi.nlm.nih.gov/pubmed/4320823
http://www.ncbi.nlm.nih.gov/pubmed/4060684http://www.ncbi.nlm.nih.gov/pubmed/10450194

Zinc

http://www.ncbi.nlm.nih.gov/pubmed/17984944
http://www.ncbi.nlm.nih.gov/pubmed/16338007
http://www.ncbi.nlm.nih.gov/pubmed/11475319
http://www.ncbi.nlm.nih.gov/pubmed/9812018

DL-Phenylalanine
http://www.ncbi.nlm.nih.gov/pubmed/335027
http://www.ncbi.nlm.nih.gov/pubmed/2243904

L-Tyrosine

One of the 22 amino acids used in the formation of neurotransmitters like dopamine and norepinephrine. It is also involved in the formation of thyroid hormones like triiodothyronine (T3) and thyroxine (T4). Supplementation has shown greater efficacy to reduce perception of stress while under stressHepatic/renal metabolism

  1. http://www.ncbi.nlm.nih.gov/pubmed/2736402
  2. http://www.ncbi.nlm.nih.gov/pubmed/7794222
  3. http://www.ncbi.nlm.nih.gov/pubmed/10230711

L-Methionine

Methionine belongs to a group of compounds called lipotropics which help the liver to process fat in the body. Once in the liver, methionine is converted into SAM(s-adenosyl methionine); SAMe is known to have a high degree of efficacy in treating various forms of depression. Methionine also converts the stronger and carcinogenic estradiol (E2) into estriol (E3) which is the “good” estrogen as compared to estradiol; imbalance is common in various form of adrenal dysfunction. Methionine supports methylation pathways, which facilitate the conversion of norepinephrine to epinephrine, essential in the adrenal cascade.

  1. http://www.ncbi.nlm.nih.gov/pubmed/20595412
  2. http://ajcn.nutrition.org/content/76/5/1151S.abstract
  3. http://www.ncbi.nlm.nih.gov/pubmed/18950248

Rhodiola Rosea

A potent adaptogen that has been the focus of much research. Rhodiola provides a buffer to stress-related mental and physical fatigue.  Rhodiola contains a glycoside known as salisdroside. This component helps combat anxiety and aging, and has been investigated for use in high-altitude sickness, as it modulates EPO gene expression. Rhodiola suppresses the production of cortisol and increases levels of stress-resistant proteins. Studies have found that it restores normal patterns of eating and sleeping after stress, & combats mental and physical fatigue by affecting RPE (perception to STRESS). Hepatic metabolism

  1. http://www.ncbi.nlm.nih.gov/pubmed/19500070
  2. http://www.ncbi.nlm.nih.gov/pubmed/23443221
  3. http://www.ncbi.nlm.nih.gov/pubmed/20378318

Octocasonol

The main component of policosanol, a lipophilic component derived from Cuban cane sugar.   While initial studies concentrated on it’s ability to affect cholesterol levels, it also has positive neurological effects specific to reaction time and Ach (acetylcholine) release.

  1. http://www.ncbi.nlm.nih.gov/pubmed/10094851
  2. http://www.ncbi.nlm.nih.gov/pubmed/10754431

Schisandra Chinensis

A vine native to northern China and Eastern Russia, commonly known as Wu Wei Zi, or “Five flavor berry”. Much of the research that ahs been done on Schisandra Chinesiswas done in Russia decades ago, hence the popularity with Eastern European athletes. Noted is the ability to both raise and lower cortisol in response to stressors.

  1. http://www.ncbi.nlm.nih.gov/pubmed/21666550
  2. http://www.ncbi.nlm.nih.gov/pubmed/18515024
  3. http://www.ncbi.nlm.nih.gov/pubmed/10228607

Bacopa Monnieri

Bacopa (aka Brahmi) is an Indian Ayurvedic herb noted for its use as a nootropic, or “mental focusing & memory enhancing” agent, and also acts protectively in neurodegeneration. It appears to work through enhancing synaptic transmission, and also acts as an anti-oxidant, hence the protective effects.

  1. http://www.ncbi.nlm.nih.gov/pubmed/23788517
  2. http://www.ncbi.nlm.nih.gov/pubmed/24252493
  3. http://www.ncbi.nlm.nih.gov/pubmed/18683852
  4. http://www.ncbi.nlm.nih.gov/pubmed/12093601

Eleutherococcus senticosus

Commonly known as Siberian Ginseng or in Chinese medicine Ci Wu Ju. Although it is not related to true ginseng (Panax ginseng), the name Siberian ginseng became popular based on potential properties similar to Panax ginseng. This adaptogenic herb has both properties of increasing work capacity and immunity. Increased work capacity is thought to be due to increased oxygen efficiency through FFA use. Immunomodulating polysaccharides or saponins isolated from Siberian ginseng stimulate macrophages, promoted antibody formation, activated complement, and increased T lymphocyte proliferation.

  1. http://www.ncbi.nlm.nih.gov/pubmed/21793317
  2. http://www.ncbi.nlm.nih.gov/pubmed/10641044
  3. http://www.ncbi.nlm.nih.gov/pubmed/11798012

Magnolia Officinalis

Another herb traditional used in Chinese medicine; the bark contains the polyphenolic compounds honokiol and magnolol, which have been found to have neuroprotective and anxiolytic activity, the latter of which is due to the effect on GABA receptors and the attenuation of cortisol-induced stress perception.

  1. http://www.ncbi.nlm.nih.gov/pubmed/16631734
  2. http://www.ncbi.nlm.nih.gov/pubmed/11408830
  3. http://www.ncbi.nlm.nih.gov/pubmed/23924268

Rehmannia Glutinosia

Also known as Yukmijihwang-tang or Chinese foxglove; it contains vitamins A, B, C, and D, as well as the active component catalpol. Regarded as a tonic herb and used in TCM for centuries, current well-controlled human data is still lacking. That said, it shows promise as a neuro-protecting agent as well as a nootropic.

  1. http://www.ncbi.nlm.nih.gov/pubmed/18407446
  2. http://www.ncbi.nlm.nih.gov/pubmed/15635169
  3. http://www.ncbi.nlm.nih.gov/pubmed/15844838
  4. http://www.ncbi.nlm.nih.gov/pubmed/17078935

Bupleurum Falcatum

Commonly known as Chinese Thoroughwax, it has been traditionally used to treat disorders of inflammation. One of the active components are saikosaponins; their metabolites have been shown to induce corticosterone activity, hence it use as an adrenal tonic in TCM. It also shows serotonergic and noradrenergic activity, and therefore used as an anti-depressant.

  1. http://www.ncbi.nlm.nih.gov/pubmed/2045012
  2. http://www.ncbi.nlm.nih.gov/pubmed/19932727
  3. http://www.ncbi.nlm.nih.gov/pubmed/22450800

Panax Ginseng

Also known as Red or Korean ginseng (not to be confused with Siberian). The predominant pharmacologically active constituents of Panax are ginsenosides; at least 25 of which have been identified and are present in variable amounts and ratios, depending on the particular species. One of the most studies herbal adaptogens in history, its efficacy in treating fatigue, mood, immune system and adrenal issues is second to none.

  1. http://www.ncbi.nlm.nih.gov/pubmed/20737519
  2. http://www.ncbi.nlm.nih.gov/pubmed/11842896
  3. http://www.ncbi.nlm.nih.gov/pubmed/16355078
  4. http://www.ncbi.nlm.nih.gov/pubmed/16401645

Plectranthus Barbatus (Forskolii)

Better known as Coleus Forskoli, the active component tis forskolin, which stimulates the cellular production of cAMP. When cAMP increases, a wide range of signaling properties can occur because of it. While much research has been done on upregulation of cAMP and fat loss, recent research suggests that cAMP affects the function of higher-order thinking in the prefrontal cortex through its regulation of ion channels. Much of the marketed focus has been on the ability to increase testosterone, which plays an integral role in the treatment of adrenal dysfunction.

  1. http://www.ncbi.nlm.nih.gov/pubmed/9029414
  2. http://www.ncbi.nlm.nih.gov/pubmed/16129715
  3. http://www.ncbi.nlm.nih.gov/pubmed/1648588

Withania Somnifera

Another Ayurvedic herb, Ashwagandha, aka Indian Ginseng, rivals that ofPanax. Ginseng in the amount of positive data available. It shows adaptogenic properties both in attenuating stress perception, altering cortisol, and increasing TTE (time to exhaustion) in trained athletes. The potentially active constituents of ashwagandha include alkaloids and steroidal lactones that together are called withanolides (particularly withaferin A), and preparations are often standardized to their percentage contents of withanolides, as with the trademarked Sensoril brand.

  1. http://www.ncbi.nlm.nih.gov/pubmed/23439798
  2. http://www.ncbi.nlm.nih.gov/pubmed/23326093
  3. http://www.ncbi.nlm.nih.gov/pubmed/22987912
  4. http://www.ncbi.nlm.nih.gov/pubmed/10956379

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